LPL Receptor
Lysophospholipid Receptor
LPL Receptor (Lysophospholipid Receptor) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans, there are eight LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg". LPL receptor ligands bind to and activate their cognate receptors located in the cell membrane. Depending on which ligand, receptor, and cell type is involved, the activated receptor can have a range of effects on the cell. These include primary effects of inhibition of adenylyl cyclase and release of calcium from the endoplasmic reticulum, as well as secondary effects of preventingapoptosis and increasing cell proliferation. Type: LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, LPAR6, S1PR1, S1PR2, S1PR3, S1PR4, S1PR5.
LPL Receptor Isoform Specific Products
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LPL Receptor Inhibitors
(65)
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LPL Receptor Agonists
(93)
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LPL Receptor Antagonists
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LPL Receptor Activators
(16)
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LPL Receptor Modulators
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LPL Receptor Control
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LPL Receptor Ligand
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LPL Receptor Related Products (278)
Related Products (278)
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Antibodies (7)
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LPL Receptor Isoform Comparison
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CAY10734
0 ImagesCat. No.: HY-50692CAS No.: 635701-59-6CAY10734 is the agonist for sphingosine-1-phosphate receptor 1 (S1P1) with an IC50 of 1.3 nM. CAY10734 promotes the recirculation of peripheral blood lymphocytes, and is a potential immunosuppressant.
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Etrasimod (Standard)
0 ImagesSynonyms: APD334 (Standard)Etrasimod (Standard) is the analytical standard of Etrasimod. This product is intended for research and analytical applications. Etrasimod (APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an IC50 value of 1.88 nM in CHO cells.
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TC LPA5 4 (Standard)
0 ImagesCat. No.: HY-107615RCAS No.: 1393814-38-4TC LPA5 4 (Standard) is the analytical standard of TC LPA5 4 (HY-107615). This product is intended for research and analytical applications. TC LPA5 4 is a LPA5 (GPR92)-specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA5-RH7777 cell line) with an IC50 of 800 nM. TC LPA5 4 displays selectivity for LPA5 over 80 other screened agent targets. TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells.
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CYM50308 (Standard)
0 ImagesCat. No.: HY-108495RCAS No.: 1345858-76-5Synonyms: ML248 (Standard)CYM50308 (Standard) is the analytical standard of CYM50308 (HY-108495). This product is intended for research and analytical applications. CYM50308 (ML248) is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. CYM50308 displays 37-fold more selective for S1P4-R than S1P5-R. CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM.
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VPC03090
0 ImagesCat. No.: HY-116516CAS No.: 1392202-91-3VPC03090 is an orally active prodrug of S1P1/3 antagonist. VPC03090 is phosphorylated by sphingosine kinase 2 (SK2) to form its active form VPC03090-P. VPC03090 reduces tumor volume in mouse breast cancer models. VPC03090 can be used in research related to breast cancer.
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VPC 01091
0 ImagesCat. No.: HY-N16096CAS No.: 2260669-84-7VPC 01091 is a S1PR3 antagonist.
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ONO-9910539
0 ImagesCat. No.: HY-120282CAS No.: 1802079-45-3ONO-9910539 is a lysophosphatidic acid receptor 1 (LPAR1) antagonist. ONO-9910539 is applicable to the research of idiopathic pulmonary fibrosis.
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ACT-209905
0 ImagesCat. No.: HY-12616CAS No.: 1062670-13-6ACT-209905 is a S1P1 receptor agonist. ACT-209905 can inhibit glioblastoma (GBM) cell growth and migration. ACT-209905 also has immunomodulating activity, and can be used in research of autoimmune diseases.
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ASP-4058 hydrochloride (Standard)
0 ImagesCat. No.: HY-111021ARCAS No.: 952510-14-4ASP-4058 hydrochloride (Standard) is the analytical standard of ASP-4058 (hydrochloride) (HY-111021A). This product is intended for research and analytical applications. ASP-4058 hydrochloride is a next-generation, selective and orally active agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.
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SEW2871 (Standard)
0 ImagesCat. No.: HY-W008947RCAS No.: 256414-75-2SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood. SEW2871 can be used for the research of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses.
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GSK-2262167 sodium
0 ImagesCat. No.: HY-18334CAS No.: 1165923-54-5GSK-2262167 sodium is a selective S1P1 receptor agonist. GSK-2262167 sodium is used for research on inflammatory and immune diseases.
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AUY954
0 ImagesCat. No.: HY-119221CAS No.: 820240-77-5AUY954 is an oral active and selective sphingosine-1-phosphate receptor 1 agonist with the EC50 values of 1.2 nM, 0.9 nM >10,000 nM, 1,210 nM, >1,000 nM, and 340 nM for hS1P2, mS1P2, S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 can be used for study of experimental autoimmune neuritis.
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BMS-986104 hydrochloride
0 ImagesCat. No.: HY-120633ACAS No.: 1622180-39-5BMS-986104 hydrochloride is a selective S1P1 receptor partial agonist, and can be used for research of autoimmune diseases.
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L-NASPA
0 ImagesCat. No.: HY-139133CAS No.: 155915-46-1L-NASPA is a ophosphatidic acid (LPA) inhibitor useful in the study of platelet activation.
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VPC 23019 (Standard)
0 ImagesCat. No.: HY-108490RCAS No.: 449173-19-7VPC 23019 (Standard) is the analytical standard of VPC 23019 (HY-108490). This product is intended for research and analytical applications. VPC 23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively) and an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively).
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ASP-4058 (Standard)
0 ImagesCat. No.: HY-111021RCAS No.: 952565-91-2ASP-4058 (Standard) is the analytical standard of ASP-4058 (HY-111021). This product is intended for research and analytical applications. ASP-4058 is a next-generation, selective and oral bioactive agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.
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S1PR1-MO-1
0 ImagesCat. No.: HY-U00366CAS No.: 1149727-61-6S1PR-MO-1 is the modulator of sphingosine-1-phosphate receptor, used for research of hyperproliferative, inflammatory diseases.
